首页> 外文期刊>International Journal of Cancer =: Journal International du Cancer >Trends in colorectal cancer incidence in Norway 1962-2006: an interpretation of the temporal patterns by anatomic subsite.
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Trends in colorectal cancer incidence in Norway 1962-2006: an interpretation of the temporal patterns by anatomic subsite.

机译:挪威1962-2006年大肠癌发病率趋势:解剖亚位点对时间模式的解释。

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摘要

There have been rapid increases in the incidence of colorectal cancer in Norway since the 1960s, and rates rank among the highest worldwide. The primary objectives are to describe trends in left- and right-sided colon cancer and rectal cancer by calendar period and birth cohort and to generate hypotheses as to the etiological factors in operation. Although the age-adjusted incidence rates of both colon and rectal cancer increased in Norway in both sexes up to the 1980s, subsite- and age-specific analyses reveal a deceleration in the rate of increase thereafter, apparent in the rates of both left-sided colon and rectal cancer. Overall trends in incidence of right-sided colon cancer continue to increase in both sexes. Rates in both left- and right-sided colon cancers have tended to stabilize or decrease among successive generations born after 1950, however, while incidence rates of rectal cancer appear to be increasing in recent generations. The all-ages rates are thus in keeping with the commonly reported left to right shift observations. The cohort patterns provide further evidence that factors earlier in life are important, and while the complex etiology makes interpretation difficult, modifications in diet, obesity and physical activity in Norway are likely among the drivers of the trends in one or more of the colorectal subsites examined. In summary, the recent downturn in the disease at younger ages provides some reason for optimism, although possible increases in rectal cancer among recent birth cohorts are of concern.
机译:自1960年代以来,挪威大肠癌的发病率迅速增加,并且其发病率位居全球之首。主要目标是按日历时期和出生队列描述左右结肠癌和直肠癌的趋势,并就手术的病因学因素提出假设。尽管直到1980年代,在挪威,按性别进行年龄调整的结肠癌和直肠癌的发病率均有所增加,但针对特定地点和特定年龄的分析显示,此后增加的速度有所降低,这在左侧和右侧的发病率中均很明显。结肠和直肠癌。男女双方右侧结肠癌发病率的总体趋势继续增加。在1950年以后出生的连续世代中,左侧和右侧结肠癌的发病率趋于稳定或下降,然而,近代直肠癌的发病率似乎正在增加。因此,所有年龄的比率都与通常报道的从左向右移位的观察一致。队列模式提供了进一步的证据,表明生命早期的因素很重要,尽管病因复杂,难以解释,但在挪威,饮食,肥胖和体育活动的改变可能是所检查的一个或多个结肠直肠亚位点趋势的驱动因素。 。总而言之,尽管最近出生的人群中直肠癌的可能增加值得关注,但最近该病在低龄时期的低迷提供了一些乐观的理由。

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