Value of Ga-67 SPECT in Monitoring the Effects of Therapy in Invasive Aspergillosis of the Sphenoid Sinus

摘要

PurposeWe report a case of invasive sphenoid sinus aspergillosis clinically presenting as a pituitary mass.MethodsAfter exploration via the trans-sphenoidal approach and subsequent treatment with amphotericin-B, Ga-67 brain SPECT was performed twice to monitor the therapeutic effect.ResultsThree months after antifungal treatment, Ga-67 brain SPECT showed partial resolution of the lesion in the sella turcica region. The patient continued with fluconazole treatment for another 2 months and received another Ga-67 brain SPECT, which showed complete clearing of the previous lesion.ConclusionGa-67 brain SPECT may play a potentially useful role in monitoring the therapeutic effect of treatment of invasive sphenoid sinus aspergillosis.