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首页> 外文期刊>International Journal of Cancer =: Journal International du Cancer >Relationship between dietary and supplemental intake of folate, methionine, vitamin B6 and folate receptor alpha expression in ovarian tumors.
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Relationship between dietary and supplemental intake of folate, methionine, vitamin B6 and folate receptor alpha expression in ovarian tumors.

机译:卵巢肿瘤中饮食和补充叶酸,蛋氨酸,维生素B6和叶酸受体α表达之间的关系。

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摘要

Because folate receptor alpha (FRalpha) is frequently over-expressed in epithelial ovarian tumors, we hypothesized that its association with folate may differ by FRalpha expression or by the timing of intake. We examined the association between folate and other cofactors in 152 ovarian cancers evaluated for FRalpha expression from the Nurses' Health Study. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. FRalpha expression was higher in serous invasive and advanced stage ovarian tumors. Recent dietary folate intake > or = 300 microg/day compared to < 300 microg/day was associated with decreased risk of developing ovarian cancer (OR = 0.62; 95%CI 0.40-0.96). There was suggestion of an increased risk with total folate (dietary and supplemental) (OR=1.42; 95%CI 0.94-2.14 for past and OR = 1.53; 95%CI 0.99-2.37 for recent intake). These results did not vary by FRalpha status of the tumor. Methyl group score, a marker of high dietary folate and methionine intake but low alcohol consumption, was inversely associated with risk of ovarian cancer (OR = 0.44; 95%CI 0.23-0.84 for past and OR=0.46; 95%CI 0.24-0.88 for recent intake). There were no clear individual associations between methionine, vitamin B(6), or multivitamin use and ovarian cancer risk overall or by FRalpha tumor status. Our data do not support the hypothesis that the relationship between factors involved in one-carbon metabolism and ovarian cancer risk differs by FRalpha status of the tumor.
机译:由于叶酸受体α(FRalpha)在上皮性卵巢肿瘤中经常过表达,因此我们推测其与叶酸的联系可能因FRalpha表达或摄入时间的不同而不同。我们检查了152个卵巢癌中叶酸与其他辅助因子之间的关联,该评估是根据Nurses's Health Study对FRalpha表达进行评估的。使用无条件逻辑回归估计多元比值比(OR)和95%置信区间(CI)。在浆液性浸润性和晚期卵巢肿瘤中,FRalpha表达较高。与<300微克/天相比,近期饮食中叶酸摄入>或= 300微克/天与患卵巢癌的风险降低相关(OR = 0.62; 95%CI 0.40-0.96)。提示总叶酸(饮食和补充)风险增加(OR = 1.42;过去摄入95%CI 0.94-2.14,最近摄入OR = 1.53; 95%CI 0.99-2.37)。这些结果没有随肿瘤的FRalpha状态而变化。甲基分数是高膳食叶酸和蛋氨酸摄入量但酒精摄入量低的标志,与卵巢癌风险呈负相关(OR = 0.44;过去95%CI 0.23-0.84; OR = 0.46; 95%CI 0.24-0.88最近的摄入量)。蛋氨酸,维生素B(6)或多种维生素的使用与总体或通过FRalpha肿瘤状态引起的卵巢癌风险之间没有明确的个体关联。我们的数据不支持这样的假说:参与一碳代谢的因素与卵巢癌风险之间的关系因肿瘤的FRalpha状态而异。

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