AbstractWe and others have previously reported that the non‐specific serotonin receptor antagonist methysergide inhibits the PRL response to ECT wheras the 5HT‐2 antagonists ketanserin and ritanserin have no effect. In the present study the effect of serotonin uptake inhibition on this neuroendocrine response was examined in two separate placebo‐controlled experiments. According to our results neither clomipramine (25 mg orally) nor fluoxetine (20 mg orally) affected the PRL response to ECT. An analysis of the placebo day data from 32 subjects indicates that a high PRL response to ECT is associated with female sex and bilateral electrode plac
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机译:摘要我们和其他人之前已经报道过,非特异性5-羟色胺受体拮抗剂甲基麦角环肽抑制PRL对ECT的反应,而5HT-2拮抗剂酮色林和利坦色林没有作用。在本研究中,在两个独立的安慰剂对照实验中检查了血清素摄取抑制对这种神经内分泌反应的影响。根据我们的结果,氯米帕明(25 mg 口服)和氟西汀(20 mg 口服)均不影响 PRL 对 ECT 的反应。对 32 名受试者的安慰剂日数据的分析表明,对 ECT 的高 PRL 反应与女性和双侧电极 plac 有关
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