Slow release of ciprofloxacin from beta- cyclodextrin containing drug delivery system through network formation and supramolecular interactions

摘要

Supramolecular cyclodextrin (CD) hydrogels have occupied an important position in developing the materials for biomedical application. In the present work an attempt has been made to improve the release profile of ciprofloxacin by designing the beta- cyclodextrin containing drug delivery system through network formation and supramolecular interactions. The polymer network has been formed by sterculia gum comprising of glucuronic acid and galacturonic acid and carbopol. The polymers have been characterization by cryo-SEMs, FTIR and C-13 solid state (NMR) and swelling studies. This article also discusses drug release, blood compatibility, mucoadhesion, gel strength and antioxidant properties of the polymers. The release of drug from beta-CD containing hydrogels was slower and less as compared to the hydrogels without beta-CD. Release of drugs from drug loaded hydrogels occurred through non-Fickian diffusion mechanism and release profile best fitted in Korsmeyer-Peppas model. These hydrogels have been found as haemocompatible, mucoadhesive, and antioxidant in nature. Mucoadhesive nature can further provide the site specific nature to drug delivery system in GIT. (C) 2016 Elsevier B.V. All rights reserved.