Impact and biocompatibility studies on Mg2+-substituted Apatite-derived 3D porous scaffolds for hard tissue engineering

摘要

The objective of this study was to develop Mg2+-substituted Apatite scaffolds by slip-casting method. The Apatite scaffolds were prepared as engineering constructs with interconnected pore structure with a pore size of 128-194 mu m range. The physicochemical properties such as crystalline phase, functional group, microstructure, pore size distribution, and elemental compositions of the scaffolds were characterized. The bioactivity of the developed porous scaffolds was investigated in Simulated Body Fluid (SBF) for various time periods (3 and 7 days). In vitro bioactivity results confirm the hydroxyl Apatite layer formation of the scaffolds and results suggest that the developed microporous scaffold could be used as suitable candidates in bone tissue engineering.