Efficient access to Unsymmetrically 3-Substituted-1,10-Phenanthrolines via Microwave Assisted Friedla ' nder Condensation with Aldehydes

摘要

abstract_textpAn efficient method with high conversion percentages (70 - 100) for the exclusive synthesis of unsymmetrical 3-functionalised-1,10-phenanthrolines via microwave assisted Friedlander condensation is presented. The method was applied to alkyl and aryl aldehydes and aldehydes containing terminal pmethoxybenzyl (PMB) protected hydroxyl moieties. Deprotec-tion of the terminal alcohol yields 3-alkyl hydroxy-1,10-phenanthrolines containing flexible alkyl linkers which have previously not been achieved. These functionalised compounds constitute key intermediates for the synthesis of flexible, unhindered 1,10-phenanthroline based systems into the future./p/abstract_text