Synthesis of novel bis(thiazoles) 19-22, 24, 25, 30 and 31 is reported. Thus, reaction of the bis(alpha-bromoketones) 14 and 15 with the corresponding thioamide derivatives 16-18 in refluxing EtOH in the presence of triethylamine afforded 19-22 in good yields. On the other hand, the novel bis(thiazoles) 24 and 25 can be synthesized by the reaction of 14 and 15 with the corresponding p-chlorobenzaldehyde thiosemicarbazones 23 in refluxing EtOH. The novel isomeric bis(thiazoles) 30 and 31 can also be synthesized by a reaction of the corresponding bis(benzaldehyde thiosemicarbazones) 27 and 28 with p-chlorophenacyl bromide 29. Compounds 27 and 28 were obtained by condensation of the corresponding bis(aldehydes) 12 and 13 with thiosemicarbazide 26.
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