Residual Dipolar Couplings by Off-Magic-Angle Spinning in Solid-State Nuclear Magnetic Resonance Spectroscopy

摘要

In solution-state NMR,residual dipolar couplings(RDCs)are an important source of molecular structural information.These interactions are introduced by adding weakly orienting media,such as lipid mixtures or bacteriophage particles,to the isotropic liquid phase.The RDCs are manifested as small changes in the splittings of spectral peaks,which are equal to the J-couplings in isotropic phase,but which contain a small dipole-dipole coupling component in an anisotropic liquid.