Expedient Ytterbium Triflate Catalyzed One-Pot Mulicomponent Synthesis of Spiroindoline-3,4 '-pyrano 2,3-cpyrazole

摘要

abstract_textpWe have synthesized a set of multi-substituted spiroindoline-, 4'-pyrano2, 3-c pyrazole from 5-chloroisatin, substituted phenyl hydrazines, 2-chloroacetonitrile/2-bromoacetonitrile/2hydroxy-1,4-naphthaquionone and ethyl acetoacetate in the presence of ytterbium triflate as catalyst in one-pot four component method at room temperature. The synthesized compounds are confirmed by FT-IR, 1D and 2DNMR spectroscopic techniques. Green synthetic methodology is adopted for the using green solvent ethanol, low temperature and easy work up which resulted in higher atom economy./p/abstract_text