Base Catalyzed Scaffold Shift from Pyranone Carboxamide to Pyrazolyl Acetamide through Intramolecular Ring Transformation

摘要

abstract_textpScaffold shift of biologically active pyranone carboxamide to pyrazolyl acetamide, which is another biologically important scaffold was achieved through one-pot base catalyzed metal-free intramolecular ring transformation. Out of the two probable mechanistic pathways (Figure 3), substitution at C-4 by hydrazineyl leading to a pyranone intermediate followed by an intramolecular attack of hydrazineyl at C-6 and decarboxylation to yield pyrazolyl acetamides was rationalized through LCMS, UV monitoring and computational studies./p/abstract_text