ABSTRACTThe β‐glucuronidase inhibitory action of milk fat globule membrane (MFGM) was studied. By increasing the MFGM concentration to 0.2, nearly 90 of the β‐glucuronidase activity was inhibited. The trypsin‐derived digests of MFGM inhibited β‐glucuronidase activity by ∼ 42. The inhibitory effect of MFGM on intestinal β‐glucuronidase of mouse was studied. We administered MFGM (groups I: 5; group II: 10; group III: 20) to mice and investigated the time course of changes in fecal β‐glucuronidase activity. In group I and II, enzyme activity had decreased 15–20 on the 5th day of treatment, but in group III, a decrease in enzyme activity was seen with an inhibition rate of 50, showing a marked intracolonic efficacy of MFGM. Thus MFGM may have potential in explaining, treating or preventin
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