The association between viruses and neurological diseases has long been documented in the medical literature. However, our understanding of viral-induced neurological injury remains limited. This is reflected by the sheer number of neurotropic viruses, the wide spectrum of clinical presentation and the complex interaction between pathogen and host immunolo-gical response 1. A recent prospective multicenter study from France, the Netherlands, and UK showed that in 464 consecutive patients presenting to hospital with nontraumatic neurological injury, 11 (2.4) had evidence of current or recent hepatitis E virus (HEV) infection 2. In this editorial, we present current evidence supporting the link between HEV and neurological injury, and question its taxology as solely a hepato-tropic virus.
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