Integrating the genotype with epigenetic marks helps develop a better understanding of the biology that underlies the complex interactions of inherited and environmental components defining the developmental origins of a range of disorders. Perinatal cohort studies offer an excellent platform to explore the origins of variation across the epigenome, especially the extent to which fixed genetic variation can moderate the relationship between prenatal environmental factors and epigenetic status at birth. The Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort is a deeply phenotyped longitudinal study that provides a unique opportunity to interrogate the health and disease outcomes for both the mother and offspring in the context of pre- and post-natal environmental influences. We have developed a 1000 genome roadmap for this cohort to interrogate the interplay between genotype, environment and inter-individual variation in the methylome in early life and its implications on offspring health outcomes. I would be presenting our findings from this roadmap and discussing the molecular and environmental determinants of disease trajectories in infancy and early childhood in relation to adiposity, child mental health, and lifestyle influences.
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