Differential Expression of beta; Amyloid Protein Precursor lpar;APPrpar; and tau mRNA in the Aged Human BrainIndividual Variability and Correlation between APPhyphen;751 and Fourhyphen;Repeat tau

摘要

We investigated the relationship between the differential expression of beta; amyloid protein precursor (APP) and tau mRNA, and the extent of beta; and tau deposition in three regions from each of the 38 aged brains obtained from consecutive autopsied cases. Remarkable variabilities were noted in the ratios of APP-770/-751/ minus;695 and four-repeat tau among elderly individuals. There was no consistent alteration in the APP differential expression among beta; plaque (-), (+), and (+ +-+ + +) groups. Also, no differences in the four-repeat tau ratios were noted among tangle (-), (+), and (++) groups. Despite these great individual variabilities, APP-751 was found to be well-correlated with four-repeat tau. It is possible that APP-751 and four-repeat tau are increasing during aging, while APP-695 and three-repeat tau are decreasing.