First electrophilic substitution of 4-methoxyindole with triethyl orthoformate as an a1-synthon

摘要

4-Methoxyindole (2) reacts with triethyl orthoformate (1a) under proton catalysis to yield the functionalized indoles3a–3ein dependence on the reaction conditions. The attack of the electrophile takes place regiospecifically at the 3-position of the indol