Urea-Catalysed Access to Novel Spirooxindole Benzopyrans via Domino Multicomponent Cascade: Approach Towards Sustainability

摘要

abstract_textpA multicomponent one-pot domino reaction of 1-hydroxy-3H-benzofchromen-3-one, isatin and malononitrile/ethyl cyanoacetate is herein investigated. The methodology concludes to synthesize diversified novel spiro-benzofpyranochromene derivatives in good to excellent yields. This method is compatible with different unsubstituted and substituted isatins bearing electron-donating and electron-withdrawing groups. The operational simplicity, short reaction time along with the gram scale up protocol make this synthetic process suitable for both academia as well as industry./p/abstract_text