Recent progress in pharmaceutical research and other chemistry-related areas have placed increasing demands on analytical methods. Combinatorial chemical synthesis and high-throughput screening, which rely on the rapid analysis of large numbers of samples, have driven profound changes in the way in which organic and pharmaceutical research is currently conducted. Consequently, a new emphasis on faster throughput has emerged in a number of analytical areas in an effort to support this new paradigm. In addition to the workhorse of fluorescence detection, new methods in mass spectrometry can now accommodate the high-throughput needs in some of these areas which may demand the analysis of thousands of compounds per day 1, 2, Similar advances in NMR spectroscopy are needed to provide additional detailed chemical information for elucidation of the structure of unknown compounds and characterization of chemical interactions on a timely basis.
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