Cu(NO3)(2)/Oxone-Mediated Radical Nitration Cyclization of 1,6-Enynes

摘要

abstract_textpHerein we report a protocol for commercial available oxone-mediated nitration cyclization between 1,6-enynes and Cu (NO3)(2). This strategy shows attractive characteristics such as mild reaction conditions, operational simplicity, broad substrates scope with good to excellent yields and high functional group tolerance. The reaction provides a regioselective way toward the formation of a new C-N and C-C bonds in one step. Mechanistic studies reveal that the procedure undergoes a radical process./p/abstract_text