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>A Physiologically Based Pharmacokinetic Assessment of Tetrachloroethylene in Groundwater for a Bathing and Showering Determination
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A Physiologically Based Pharmacokinetic Assessment of Tetrachloroethylene in Groundwater for a Bathing and Showering Determination
A two‐step methodology is described to make a health‐based determination for the bathing and showering use of the water from a private well contaminated with volatile organic chemicals. The chemical perchloroethylene (PERC) is utilized to illustrate the approach. First, a chemical‐specific exposure model is used to predict the concentration of PERC in the shower air, shower water, and in the air above the bathtub. Second, a physiologically based pharmacokinetic (PBPK) model is used to predict the concentration of PERC delivered to the target tissue, the brain, since the focus is on neurological endpoints. The simulation exercise includes concurrent dermal and inhalation routes of exposure. A reference target tissue level (RTTL) in the brain is estimated using the PBPK model. A hazard index based on this benchmark guideline is used to make a regulatory determination for bathing and showering use of the contaminated
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机译:描述了一种两步法,用于对被挥发性有机化学物质污染的私人水井中的水的沐浴和淋浴使用进行基于健康的确定。利用化学全氯乙烯(PERC)来说明该方法。首先,使用特定化学品暴露模型来预测淋浴空气、淋浴水和浴缸上方空气中PERC的浓度。其次,基于生理学的药代动力学 (PBPK) 模型用于预测输送到靶组织(大脑)的 PERC 浓度,因为重点是神经终点。模拟练习包括同时进行的皮肤和吸入暴露途径。使用 PBPK 模型估计大脑中的参考目标组织水平 (RTTL)。基于该基准指南的危害指数用于对受污染的沐浴和淋浴使用进行监管确定
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