Oxygen controlled batch cultivations of Schizophyllum commune for enhanced production of branchedβ-1,3-glucans

摘要

Oxygen and shear stress are the key factors for enhanced glucan production with Schizophyllum commune. During batch cultivation control of$$P_{O_2 } $$or$$q_{O_2 } $$(specific oxygen uptake rate) was achieved by variation of the impeller speed. Biomass was modelled by using the carbon and oxygen balance derived from exhaust data. At mycel growth a$$q_{O_2 } $$of 0.042 h−1presents just the border before oxygen limitation arises and is simultaneously the optimum operation condition for maximum glucan formation. Related to an overall cultivation time of 72 h a maximum of both productivity (4.3 kg m−3d−1) and yield (13 kg m−3) were o