PurposeThis study evaluated the use of Tc-99m DTPA renography in patients with collagen disease.Materials and MethodsTc-99m DTPA renal scintigraphy was performed in 28 patients with clinically diagnosed collagen disease. Twenty-two other patients who underwent renal scintigraphy and were subsequently shown to have no kidney abnormalities served as the control group.ResultsOne quarter of the patients with collagen disease had abnormal findings of renography, despite the absence of abnormal laboratory data. Renograms were 100percnt; sensitive for the detection of renal disease in patients with collagen disease, and their specificity was 53percnt; when serum blood urea nitrogen, serum creatinine concentration, and proteinurea were the only measures of renal impairment considered. The glomerular filtration rate was not significantly different between the groups, but the bilateral time to peak was significantly greater in the patients with collagen disease. Hydronephrosis was present in 7percnt; of patients with collagen disease.ConclusionRenography is useful for detecting early changes of renal involvement when the clinical state of collagen disease is evaluated.
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