机译:Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief
Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, BR-14049900 Ribeirao Preto, Brazil;
Dompe SpA Res Ctr, Dept Discovery, I-67100 Laquila, Italy;
Univ Parma, Dipartimento Farm, I-43121 Parma, ItalyALTA Ric & Sviluppo Biotecnol Srlu, I-67100 Laquila, ItalyUniv Milan, Dept Biomed Surg & Oral Sci, I-20133 Milan, ItalyUniv Milan, Dept Med Biotecnol & Translat Med, I-20129 Milan, ItalyUniv Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Immunol, BR-31270901 Belo Horizonte, MG, Brazil;
C5a; inflammatory pain; neuropathic pain; allosteric antagonism; GPCR;