Uptake and elimination kinetics of organophosphorous pesticides in the guppy(poecilia reticulata): Correlations with the octanol/water partition coefficient

摘要

AbstractBioconcentration factors, uptake rate constants and elimination rate constants of a series of organophosphorous pesticides were determined in the guppy(Poecilia reticulata).The results of these three toxicokinetic parameters were related to measured octanol/water partition coefficients (Kow). A simple one‐compartment model fitted the uptake and elimination characteristics of the chemicals. A biphasic relationship was observed between logk1(uptake rate constant) and logKow, whereas elimination rate constants were inversely related toKow. For some of the test compounds substantially higher elimination rates were found, compared to isolipophilic chlorobenzenes, which resulted in lower bioconcentration factors. This divergent behavior is discussed in view of possible biotransformation reactions for these compound