Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis

Marampon F.; Gravina G. L.; Festuccia C.Popov V. M.Colapietro E. A.Sanita P.Musio D.De Felice F.Lenzi A.Jannini E. A.Di Cesare E.Tombolini V.

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Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis

机译：Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis

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Purpose Radiotherapy toxicity is related to oxidative stress-mediated endothelial dysfunction. Here, we investigated on radioprotective properties of Vitamin D (Vit.D) on human endothelial cells (HUVEC).

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来源
《Journal of endocrinological investigation.》 |2016年第4期|411-422|共12页
作者
Marampon F.; Gravina G. L.; Festuccia C.Popov V. M.Colapietro E. A.Sanita P.Musio D.De Felice F.Lenzi A.Jannini E. A.Di Cesare E.Tombolini V.;
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作者单位

Univ Aquila, Div Radiotherapy & Radiobiol, Dept Biotechnol & Appl Clin Sci, I-67100 Laquila, Italy;

Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA;

Univ Roma La Sapienza, Dept Radiotherapy, Policlin Umberto I, Piazzale Aldo Moro 5, I-00185 RomeUniv Roma La Sapienza, Dept Expt Med, I-00185 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, I-00133 Rome, Italy;

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正文语种英语
中图分类内分泌腺疾病及代谢病;
关键词
Vitamin D; Endothelium; Oxidative stress; Radiotherapy; SirT1;

Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis

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