The influences of carbofuran on lipid profile in blood plasma as well as liver, kidneys and brain tissues which connected with the oxidative shunt of pentose phosphate pathway (glucose-6-phosphate dehydrogenase (G6PD) and 6-phaospho-gluconate dehydrogenase (6PGD)) enzymes were determined. Also the alleviation of carbofuran toxicity using parsley and its methanolic extract (ingestion and injection) was studied. Carbofuran was ingested orally at dose of 1/20 LD50 for 3 months (one dose every 48 hours). Lipid profile such as total lipids, cholesterol, triglycerides, phospholipids and LDL-C contents of serum, liver, kidneys and brain were increased in carbofuran intoxicated rats relative to control, but the content of HDL-C was unchanged relative to control. The same trend was observed for G6PD and 6PGD activities of liver, kidneys and brain cytosols as well as serum of intoxicated animals which connected and associated with lipid anabolism. The carbofuran ingestion significantly augmented the both enzyme activities relative to control animals. It can be concluded that, the three parsley treatments as antioxidative agents ameliorated the desirable influences of the pesticide these may be due to the lipotropic factors of parsley. The values of lipid profile fractions were still higher in treated intoxicated rats than those of normal health control.
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