The Preparation and Evaluation of Sodium and Alkylammonium Montmorillonite and Polysaccharide Nanocomposites as Sustained Release Excipients

摘要

Nanotechnology has contributed to the creation of several products and industrial methods.Herein we tested the intercalation of biomaterials into inorganic nanolamellae as pharmaceutical excipients.These materials included sodium and alkylammonium montmorillonite,viscogel B8,ethylcellulose,and chitosan,and the intercalation results success was observed with ethylcellulose and viscogel B8.Thus this nanocomposite was tested with dapsone pills as a model in simulated gastric and enteral fluids and showed a close zero order type kinetics and a higher drug release retardation.This data suggests that this nanocomposite has potential not only for colon specific use but also for prolonged release systems coatings.