Silica gel-promoted new one-pot procedure for the synthesis of 1,3-oxathiolan-5-one

摘要

A highly selective two-component silica gel-promoted synthesis of 1,3-oxathiolan-5-one derivatives in N, N-Dimethylformamide (DMF) is presented. The reaction was carried out using aromatic aldehyde and mercaptoacetic acid in the presence of silica gel in DMF with heating. The reactions were worked up by separating the silica gel and recovering the solid product after adding water in excellent yields without any chromatographic purification. Structures of the compounds were satisfactorily confirmed by H-1 NMR and LCMS spectral analysis.