Synthesis of derivatives of 3-acetyl-2-aminopyrrole and pyrolo2,3-dpyrimidine from monoacetylketene aminals

摘要

A new scheme for the synthesis of pyrrolo2,3-dpyrimidines from monoacetylketene animals was proposed. Reactions of monoacetylketeneN-benzoyl- andN-acetylaminals with α-bromoacetophenone afforded the corresponding 3-acetyl-2-acylamino-5-phenyl- lH-pyr-roles, which underwent cyclization to 2,4,6-trisubstituted 7Hl-pyrrolo2,3-dpyrimidines under the action of ammonium acetate in boiling BuOH