Unprecedented Synthesis of 2-Aminochromones and 2-Aminoquinolones through an Electrophilic C-Cyanation and 6-exo-dig Cyclization Cascade with the Intermediary of beta-Ketonitriles

摘要

For the first time, a domino electrophilic cyanation, using environmentally benign electrophilic cyanating reagent N-cyano-N-phenyl-p-toluenesulfonamide (NCTS) to form beta-ketonitriles, and 6-exo-dig cyclization were employed for the synthesis of 2-aminochromones and 2-aminoquinolones in very good yields. This protocol can also be regulated to get beta-ketonitriles as the products.