Synergistic Catalysis of Ag(I) and Organo-N-heterocyclic Carbenes: One-Pot Synthesis of New Anticancer Spirooxindole-1,4-dihydropyridines

摘要

abstract_textpAg(I)/organo-NHC catalyst pair (Lewis acidic/basic) delivered from labile Ag(I)-NHC complex in ethanol has shown synergistic effect to catalyze the one-pot four-component reaction of isatins, malononitrile, cyclic ketones and ammonium acetate to produce new series of spirooxindole-1,4-dihydropyridine scaffolds. Carbene trapping from pre-synthesized Ag(I)-NHC in the form of zwitterionic CS2-NHC adduct in ethanol provides evidence for the proposed synergistic catalysis. Besides, preliminary results of anticancer activity of these new spirooxindole-1,4-dihydropyridines are also presented./p/abstract_text