In this article, we study the existence of gradings on finite dimensional associative algebras. We prove that a connected algebra A does not have a nontrivial grading if and only if A is basic, its quiver has one vertex, and its group of outer automorphisms is unipotent. We apply this result to prove that up to graded Morita equivalence there do not exist nontrivial gradings on the blocks of group algebras with quaternion defect groups and one isomorphism class of simple modules.
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