Definition of Platelet-Derived Histamine-Releasing Factor and Histaminergic Receptors Modulating Platelet Aggregation

摘要

Endogenous and exogenous free radical scavengers significantly decrease mast cell histamine release induced by coincubation with resting, activated platelets or with platelet-derived supernatant. Histamine and pyridylethylamine dose-dependently enhance platelet aggregation; the effect is potentiated by ranitidine and blocked by mepyramine. Histamine increases also cytosolic calcium concentration in platelets stimulated with thrombin, and binding sites for 3H-mepyramine are present on platelet membranes.