Selectfluor-promoted Synthesis of 2,4-and 2,6-Diarylpyridines Through Annulation of Aromatic Ketones with an Ammonium Source in DMF

摘要

An efficient one-pot four-component condensation and cyclization of ketones with DMF and ammonium acetate for the synthesis of 2,4-diarylsubstituted pyridines promoted by Selectfluor has been achieved. Symmetrical pyridines were obtained selectively when non-methyl ketones were used as the starting materials. Two C-C and C-N bonds are formed during the oxidative cyclization process.