About 1–6 of the genetic ancestry of modern humans today originates from admixture with archaic humans. It has recently been shown that autosomal genomic regions with a reduced proportion of Neanderthal and Denisovan ancestries (NA and DA) are significantly enriched in genes that are more expressed in testis than in other tissues. To determine whether a cellular segregation pattern would exist, we combined maps of archaic introgression with a cross-analysis of three transcriptomic datasets deciphering the transcriptional landscape of human gonadal cell types. We reveal that the regions deficient in both NA and DA contain a significant enrichment of genes transcribed in meiotic germ cells. The interbreeding of anatomically modern humans with archaic humans may have introduced archaic-derived alleles that contributed to genetic incompatibilities affecting meiosis that were subsequently purged by natural selection.
展开▼
机译:今天现代人类大约1-6%的遗传祖先起源于与古人类的混合。最近研究表明,尼安德特人和丹尼索瓦人祖先(NA 和 DA)比例较低的常染色体基因组区域在睾丸中表达的基因比其他组织中表达得更多。为了确定是否存在细胞分离模式,我们将古老渗入图谱与三个转录组数据集的交叉分析相结合,破译了人类性腺细胞类型的转录景观。我们发现,NA 和 DA 均缺乏的区域包含减数分裂生殖细胞中转录的基因的显着富集。解剖学上的现代人类与古人类的杂交可能引入了古老的衍生等位基因,这些等位基因导致了影响减数分裂的遗传不相容性,随后被自然选择清除。
展开▼