Summary—Our aim was to document possible alterations of theophylline pharmacokinetics in rats during fever. Two groups (group A = normothermic controls, group B = fever‐induced animals) of Wistar AF IOPS male rats were injected at 19 30 h either with 2 g/kg of brewer's yeast subcutaneously (20 w/v) or with the equivalent volume of saline. Twelve hours later at 07 30 h the two groups received a single 12 mg/kg/IP dose of theophylline. Blood samples were obtained by retro‐orbital sinus puncture 0, 0.25, 0.5, 1, 2, 4, 8, 12, 16 and 24 hours after administration. A third group of 10 male IOPS rats (group C) were used under the same experimental conditions in order to determine the influence of brewer's yeast‐induced fever on biological parameters. Cmax, Tmax, Cmax/Tmax, T 1/2, Cl, Vd and AUC were determined according to a one‐compartment open model. Our results confirm the fever‐induced decrease in total plasma proteins and albumin but do not demonstrate any significant change in theophylline pharmacokinetic
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