High endothelial venules of the rat lymph node - A review and a question: Is their activity antigen specific?

摘要

abstract_textpBackground: The high endothelial venules (HEVs) of the lymph nodes are sites for transvascular lymphocyte traffic. Due mostly to the wide scale of variations manifested by the HEVs and to frequently restricted conditions of observation, reports often differed on their morphological or functional features, which has led to opposing views on aspects of the functioning of HEVs./ppMethods: In the present review, we analyze previous reports and attempt to derive comprehensive proposals to reconcile variations in actual observations under diverse conditions./ppResults: This analysis shows that the features typical of the HEV endothelial cells (HEV cells) are stimulated to emerge by antigens and the proper lymphocytes and mediators. The stimulation would implicate drained lymphocytes migrating in the perivascular channel, immediately cuffing an HEV's endothelium. A marked pleomorphism of HEV cells betrays the fact that they undergo individual stimulation and a somewhat heterogeneous activity. Other facts indicate that the subendothelial spaces of HEV cells are sites of interactions between drained lymphocytes, HEV cells, and recruited blood lymphocytes. Facts also reveal time- and site-related variations in the intensity of recruitment of blood lymphocytes by HEV cells and topographically related variations in the nature of the recruited cells./ppConclusions: Analysis of same other observations, often ignored, lead to the conclusion that recruitment of lymphocytes by HEV cells for the sake of participating in local specific immune activities is antigen specific, despite the implication of homing receptors of lymphocytes. (C) 1996 Wiley-Liss, Inc./p/abstract_text