This article reviews recent work by investigators examining modifications in lipid and protein intake and their subsequent effects on various measured parameters. Structured triglycerides were demonstrated to decrease plasma high-density lipoprotein cholesterol and positively effect the muscle fractional synthetic rate. In addition, structured triglycerides modify the plasma membrane lipid composition, the effects of which are yet to be determined. Several additional studies have produced encouraging results in patients with hepatic dysfunction. Another recent report suggests a possible relationship between low levels of the (omega;-3) fatty acid, docosahexaenoic acid, and encephalopathy in cirrhotic patients. Additionally, there continues to be active research into specific individual amino acid (glutamine, arginine), dipeptide, ketoacid, and nucleotide supplementation and their effects on muscle fractional synthetic rates and intestinal mucosal viability.
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