Summary. Haemopoietic cells with pluripotent capabilities, were grown in soft‐gel cultures from the peripheral blood of a glucose‐6‐phosphate dehydrogenase (G6PD) electrophoretic A,B heterozygous female with chronic myelocytic leukaemia (CML). The cells produced mixed colonies composed of erythrocytic and granulocytic progeny. Only type B isoenzyme of G6PD was found in mixed colonies, in mature neutrophils, erythrocytes, and committed granulocyte and erythrocyte stem cells. The fibroblasts of the patient contained both A and B isoenzymes of G6PD. This study provides direct evidence that a pluripotent haemopoietic stem cell is involved in the malignant clone i
展开▼
