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Transferrin Decorated Thermoresponsive Nanogels as Magnetic Trap Devices for Circulating Tumor Cells

机译:转铁蛋白修饰的热响应纳米凝胶作为循环肿瘤细胞的磁性捕获装置

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摘要

A rational design of magnetic capturing nanodevices, based on a specific interaction with circulating tumor cells (CTCs), can advance the capturing efficiency and initiate the development of modern smart nanoformulations for rapid isolation and detection of these CTCs from the bloodstream. Therefore, the development and evaluation of magnetic nanogels (MNGs) based on magnetic nanoparticles and linear thermoresponsive polyglycerol for the capturing of CTCs with overexpressed transferrin (Tf+) receptors has been presented in this study. The MNGs are synthesized using a strain-promoted "click" approach which has allowed the in situ surface decoration with Tf-polyethylene glycol (PEG) ligands of three different PEG chain lengths as targeting ligands. An optimal value of around 30 of cells captures is achieved with a linker of eight ethylene glycol units. This study shows the potential of MNGs for the capture of CTCs and the necessity of precise control over the linkage of the targeting moiety to the capturing device.
机译:基于与循环肿瘤细胞(CTCs)的特定相互作用,合理设计磁捕获纳米器件可以提高捕获效率,并启动现代智能纳米制剂的开发,用于从血液中快速分离和检测这些CTC。因此,本研究提出了基于磁性纳米颗粒和线性热响应聚甘油的磁性纳米凝胶(MNGs)的开发和评估,用于捕获具有过表达转铁蛋白(Tf+)受体的CTC。MNGs是使用菌株促进的“点击”方法合成的,该方法允许使用三种不同PEG链长的Tf-聚乙二醇(PEG)配体作为靶向配体进行原位表面修饰。使用8个乙二醇单元的接头可实现约30%的细胞捕获的最佳值。本研究显示了MNG捕获CTCs的潜力,以及精确控制目标部分与捕获装置的联系的必要性。

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