Combined treatment with terbutaline and aminophylline inhibits experimental amyloidosis in mice

摘要

AbstractObjective. To investigate the effects of drugs known to elevate adenosine 3':5'‐cyclic monophosphate (cAMP) on experimental amyloidosis.Methods. A β2‐agonist, terbutaline, and a phosphodiesterase inhibitor, aminophylline, were administered in combination in a mouse model of amyloidosis induced by inflammatory stimulation with silver nitrate. Amyloidosis was quantitated by radioimmunoassay for splenic amyloid A (AA) protein.Results. At the doses selected, aminophylline/ terbutaline inhibited splenic amyloid deposition more potently than did colchicine, a known inhibitor of amyloidosis.Conclusion. Drugs known to elevate cAMP inhibit experimental mouse AA amyloid