Effect of Centchroman (67/20) and 78/224 on nucleic acid and protein biosynthesis during implantation in rats

摘要

The biosynthesis of nucleic acids and proteins was studied in rat uterus by following the incorporation of 3H-thymidine, 3H-uridineand14C-leucinein control and pregnant rats in the presence and absence of two anti-implantation drugs. One of the drugs, 78/224 caused a significant increase in incorporation whereas the other drug, Centchroman, caused an inhibition in incorporation of all the three precursors. The implications of these changes in the light of estrogenicity, agonist and antagonist actions of anti-estrogens have been analysed. The importance of homeostatic mechanisms involved in nucleic acids and proteins for the maintenance of constant internal milieu for blastocyst attachment has been discussed.