Antibiofilm properties of triclosan with EDTA or cranberry as Foley Catheter lock solutions

摘要

titleAbstract/titlesectiontitleAims/titlepTo investigate the efficiency of triclosan, ethylenediaminetetraacetic acid (EDTA) and cranberry alone or in combinations against iEscherichia coli/i strains as urinary catheter lock solutions to reduce catheter‐associated urinary tract infections./p/sectionsectiontitleMethods and Results/titlepViable counting was used to assess antibiofilm activities for triclosan, EDTA and cranberry alone or in combinations against iE. coli/i strains embedded in biofilm onto all‐silicon Foley catheter surface. The results revealed that combination of triclosan (10 mg mlsup−1/sup/EDTA 30 mg mlsup−1/sup) when filling the catheter balloon was able to eradicate and prevent biofilm formation among all tested iE. coli/i including the resistant strains, whereas triclosan (8·5 mg mlsup−1/sup)/ cranberry (103 mg mlsup−1/sup) combination was a successful catheter lock solution by preventing all tested strains from adhering onto catheter surface when filled ivia/i the eye hole./p/sectionsectiontitleConclusions/titlepThe combinations of triclosan/EDTA and triclosan/cranberry were significantly effective in eradicating and preventing biofilm formation of the tested iE. coli/i strains on Foley catheters./p/sectionsectiontitleSignificance and Impact of the Study/titlepCombinations of triclosan/EDTA and triclosan/cranberry have a promising application as nonantibiotic catheter lock solution./p/section