Influence of ventilatory technique on pulmonary baroinjury in baboons with hyaline membrane disease

摘要

AbstractTo assess the influence of ventilatory technique on pulmonary baroinjury in experimental hyaline membrane disease, we randomized 24 premature baboons to six treatment groups according to ventilator (PPV, positive pressure ventilator; HFO, high frequency oscillator; HFI, high frequency flow interrupter) and O2therapy Flo2as clinically indicated, or Flo21.0). PaCO2was adjusted by varying pressure amplitude, and for PPV, also by rate (1 wk. Management of premature baboons with HFO and appropriate O2resulted in less severe airleak, 100 survival, and no evidence of severe tracheal injury or BPD. These outcomes were not achieved with clinically similar strategies using PPV or HFI.