Pancreatic tumors were induced in guinea fowls inoculated with virus strain Pts-56. Sequential high-resolution light microscopic and ultrastructural studies revealed consecutive occurrence of alterations in the pancreas of the infected birds. From the second month p.i. there were nonobligatory, unspecific focal degenerative changes in acinar units that were replaced by tubular complexes, lined with centroacinar-like cells. From the third month, proliferation of ductule structures with mucin-producing or mucinnonproducing epithelium occurred, giving rise to cystic and papillary adenomas. From the fourth to sixth months, pancreatic adenocarcinomas and poorly differentiated carcinomas arose.
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