Rats of a Sprague-Dawley strain were infected with embryonated Ascaris Suum eggs. Infected rats examined ‘i>postmortem’7 days after infection showed characteristic pathological changes in the liver and lung. Most of the sera from infected animals had reaginic antibodies in titers ranging from 1:160 after a primary infection to 1:4,000 after a second infection. The reaginic antibodies were detected by homologous PCA reactions using Ascaris crude extract or a purified Ascaris allergen (Asc-1) as challenge. The results indicated therefore that Asc-1 was present in all stages of the parasite life cycle and was directly involved in stimulating reagin production during the migratory phase of the infect
展开▼
