Serendipitous Detection of Cushingrsquo;s Disease by FDG Positron Emission Tomography and a Review of the Literature

摘要

A 70-year-old woman was referred for F-18 fluorodeoxyglucose (FDG) positron emission tomographic (PET) imaging of the brain to evaluate progressive dementia and neuropsychiatric symptoms. Although she had a history of hypertension and diabetes mellitus, she did not exhibit phenotypic features of Cushingrsquo;s disease. The FDG-PET images revealed marked FDG uptake in the pituitary gland but no evidence of degenerative dementia. Two macroadenomas were confirmed by magnetic resonance imaging. Endocrinologic evaluation revealed Cushingrsquo;s disease. After surgical resection of the tumors, the patientrsquo;s symptoms decreased markedly.