Synthesis of 1,7-Bis(4-Hydroxyphenyl)-3-Hydroxy-1,3-Heptadiene-5-One, an Antiplatelet Diarylheptanoid fromAlpinia blepharocalyxK. Schum

摘要

A general and straight forward total synthesis of 1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadiene-5-one (5) starting from 4-methoxycinnamic acid (6) via ethyl 5-(4-methoxyphenyl)-3-hydroxy-2,4-pentadienoate (14) was accomplished in 19 overall yield.