AbstractThe pharmacokinetic profile of ketoprofen suppositories following single and chronic (32 doses) administration to 12 healthy adult male volunteers was established. Each subject received a single rectal dose of 100 mg of ketoprofen on day 1, followed by one suppository of 100 mg b.i.d. for days 8–22, and finally one suppository on day 23. Plasma samples were analysed by gas‐liquid chromatography. Following single doses, the mean maximum observed concentrations of ketoprofen in plasma (6·56 μg ml−1) were achieved at 1·1 h; the mean elimination half‐life was 1·78 h. The results indicate that ketoprofen is rapidly and reproducibly absorbed and eliminated from the suppositor
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