Progress toward resolving the possible linkage of multiple endocrine neoplasia type 2A to haptoglobin and group‐specific loci: Use of restriction fragment length polymorphisms extends exclusion region

摘要

AbstractIn an earlier paper, positive but nonsignificant lod scores were found in pair‐wise linkage tests between multiple endocrine neoplasia type 2A (MEN‐2A) and both the haptoglobin (HP) locus on chromosome 16 and group‐specific component (GC) locus on chromosome 4. Recently discovered restriction fragment length polymorphisms forHPand for metallothionein 2 processed pseudogene 1 (MT2P1) nearGChave made it possible to carry out a more powerful set of linkage tests with MEN‐2A. This paper reports the results of such linkage analyses employing both pair‐wise and multipoint tests. Close linkage ofHPon chromosome 16 and MEN‐2A is excluded. Linkage of MEN‐2A on chromosome 4 withGCis excluded on theMT2P1side ofGCin a 7‐centimorgan inter